TY  - GEN
AU  - Xu,Yi
AU  - Dalrymple,Susan L
AU  - Becker,Robyn E
AU  - Denmeade,Samuel R
AU  - Isaacs,John T
TI  - Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers
SN  - 1078-0432
PY  - 2007///1129
KW  - 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
KW  - genetics
KW  - 5-alpha Reductase Inhibitors
KW  - Administration, Oral
KW  - Animals
KW  - Azasteroids
KW  - chemistry
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - drug effects
KW  - Chromatography, Liquid
KW  - methods
KW  - Dihydrotestosterone
KW  - administration & dosage
KW  - Disease Models, Animal
KW  - Dutasteride
KW  - Enzyme Activation
KW  - Enzyme Inhibitors
KW  - Finasteride
KW  - Gene Expression Profiling
KW  - Humans
KW  - Male
KW  - Mass Spectrometry
KW  - Mice
KW  - Mice, Nude
KW  - Molecular Conformation
KW  - Prostatic Neoplasms
KW  - drug therapy
KW  - Protein Isoforms
KW  - antagonists & inhibitors
KW  - RNA, Messenger
KW  - Rats
KW  - Reverse Transcriptase Polymerase Chain Reaction
KW  - Structure-Activity Relationship
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1158/1078-0432.CCR-06-0184
ER  -