A novel endothelin receptor antagonist CPU0213 improves diabetic cardiac insufficiency attributed to up-regulation of the expression of FKBP12.6, SERCA2a, and PLB in rats. [electronic resource]
- Journal of cardiovascular pharmacology Jun 2006
- 729-35 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0160-2446
10.1097/01.fjc.0000211765.52012.aa doi
Animals Aspartic Acid Endopeptidases--biosynthesis Blood Pressure Blotting, Western Calcium-Binding Proteins--biosynthesis Cardiomyopathies--drug therapy Diabetes Complications--drug therapy Diabetes Mellitus, Experimental Down-Regulation Endothelin Receptor Antagonists Endothelin-Converting Enzymes Heart Rate Male Metalloendopeptidases--biosynthesis Myocardium--metabolism Nitric Oxide Synthase Type II--biosynthesis Organ Size Oxidative Stress Pyrazoles--therapeutic use RNA, Messenger--analysis Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Ryanodine Receptor Calcium Release Channel--biosynthesis Sarcoplasmic Reticulum Calcium-Transporting ATPases--biosynthesis Streptozocin Tacrolimus Binding Protein 1A--biosynthesis Up-Regulation Vasoconstrictor Agents--therapeutic use