TY  - GEN
AU  - Moore,C S
AU  - Earl,N
AU  - Frenette,R
AU  - Styhler,A
AU  - Mancini,J A
AU  - Nicholson,D W
AU  - Hebb,A L O
AU  - Owens,T
AU  - Robertson,G S
TI  - Peripheral phosphodiesterase 4 inhibition produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) prevents experimental autoimmune encephalomyelitis
SN  - 0022-3565
PY  - 2006///1102
KW  - 3',5'-Cyclic-AMP Phosphodiesterases
KW  - antagonists & inhibitors
KW  - Animals
KW  - Body Weight
KW  - drug effects
KW  - Cyclic Nucleotide Phosphodiesterases, Type 4
KW  - Encephalomyelitis, Autoimmune, Experimental
KW  - prevention & control
KW  - Glial Fibrillary Acidic Protein
KW  - analysis
KW  - Lipopolysaccharides
KW  - pharmacology
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Multiple Sclerosis
KW  - drug therapy
KW  - Phosphodiesterase Inhibitors
KW  - therapeutic use
KW  - Proto-Oncogene Proteins c-fos
KW  - Pyridines
KW  - Rolipram
KW  - Spinal Cord
KW  - pathology
KW  - Tumor Necrosis Factor-alpha
KW  - biosynthesis
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1124/jpet.106.106096
ER  -