Moore, C S <br/><br/>
Peripheral phosphodiesterase 4 inhibition produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) prevents experimental autoimmune encephalomyelitis.  [electronic resource] 

 -  The Journal of pharmacology and experimental therapeutics  Oct 2006 
 - 63-72 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0022-3565 
<br/><br/><label>Standard No.: </label>10.1124/jpet.106.106096  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>3',5'-Cyclic-AMP Phosphodiesterases--antagonists & inhibitors<br/>Animals<br/>Body Weight--drug effects<br/>Cyclic Nucleotide Phosphodiesterases, Type 4<br/>Encephalomyelitis, Autoimmune, Experimental--prevention & control<br/>Glial Fibrillary Acidic Protein--analysis<br/>Lipopolysaccharides--pharmacology<br/>Mice<br/>Mice, Inbred C57BL<br/>Multiple Sclerosis--drug therapy<br/>Phosphodiesterase Inhibitors--therapeutic use<br/>Proto-Oncogene Proteins c-fos--analysis<br/>Pyridines--therapeutic use<br/>Rolipram--therapeutic use<br/>Spinal Cord--pathology<br/>Tumor Necrosis Factor-alpha--biosynthesis