TY  - GEN
AU  - Tokarski,John S
AU  - Newitt,John A
AU  - Chang,Chieh Ying J
AU  - Cheng,Janet D
AU  - Wittekind,Michael
AU  - Kiefer,Susan E
AU  - Kish,Kevin
AU  - Lee,Francis Y F
AU  - Borzillerri,Robert
AU  - Lombardo,Louis J
AU  - Xie,Dianlin
AU  - Zhang,Yaqun
AU  - Klei,Herbert E
TI  - The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants
SN  - 0008-5472
PY  - 2006///0727
KW  - Animals
KW  - Benzamides
KW  - Crystallography, X-Ray
KW  - Dasatinib
KW  - Drug Resistance, Neoplasm
KW  - Enzyme Activation
KW  - Humans
KW  - Imatinib Mesylate
KW  - Models, Molecular
KW  - Piperazines
KW  - chemistry
KW  - Protein Conformation
KW  - Protein Kinase Inhibitors
KW  - Protein Structure, Tertiary
KW  - Proto-Oncogene Proteins c-abl
KW  - antagonists & inhibitors
KW  - Pyrimidines
KW  - Structure-Activity Relationship
KW  - Thiazoles
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1158/0008-5472.CAN-05-4187
ER  -