TY - GEN AU - Arumugam,Thiruma V AU - Chan,Sic L AU - Jo,Dong-Gyu AU - Yilmaz,Gokhan AU - Tang,Sung-Chun AU - Cheng,Aiwu AU - Gleichmann,Marc AU - Okun,Eitan AU - Dixit,Vishwa D AU - Chigurupati,Srinivasulu AU - Mughal,Mohamed R AU - Ouyang,Xin AU - Miele,Lucio AU - Magnus,Tim AU - Poosala,Suresh AU - Granger,D Neil AU - Mattson,Mark P TI - Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke SN - 1078-8956 PY - 2006///0907 KW - Amyloid Precursor Protein Secretases KW - Animals KW - Apoptosis KW - Aspartic Acid Endopeptidases KW - antagonists & inhibitors KW - Brain KW - cytology KW - Brain Ischemia KW - metabolism KW - Cells, Cultured KW - Endopeptidases KW - genetics KW - Enzyme Inhibitors KW - Humans KW - Leukocytes KW - Mice KW - Mice, Knockout KW - Mice, Transgenic KW - Microglia KW - Neurons KW - Peptides KW - Rats KW - Receptor, Notch1 KW - Reperfusion Injury KW - Signal Transduction KW - physiology KW - Stroke KW - Treatment Outcome N1 - Publication Type: Journal Article; Research Support, N.I.H., Intramural UR - https://doi.org/10.1038/nm1403 ER -