Zheng, Hong

RANKL stimulates inducible nitric-oxide synthase expression and nitric oxide production in developing osteoclasts. An autocrine negative feedback mechanism triggered by RANKL-induced interferon-beta via NF-kappaB that restrains osteoclastogenesis and bone resorption. [electronic resource] - The Journal of biological chemistry Jun 2006 - 15809-20 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

0021-9258

10.1074/jbc.M513225200 doi


Animals
Base Sequence
Bone Resorption
Carrier Proteins--physiology
Cell Line
DNA Primers
Enzyme Inhibitors--pharmacology
Interferon-beta--biosynthesis
Membrane Glycoproteins--physiology
Mice
NF-kappa B--metabolism
Nitric Oxide--biosynthesis
Nitric Oxide Synthase Type II--antagonists & inhibitors
Osteoclasts--enzymology
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B
Reverse Transcriptase Polymerase Chain Reaction