RANKL stimulates inducible nitric-oxide synthase expression and nitric oxide production in developing osteoclasts. An autocrine negative feedback mechanism triggered by RANKL-induced interferon-beta via NF-kappaB that restrains osteoclastogenesis and bone resorption. [electronic resource]
- The Journal of biological chemistry Jun 2006
- 15809-20 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
0021-9258
10.1074/jbc.M513225200 doi
Animals Base Sequence Bone Resorption Carrier Proteins--physiology Cell Line DNA Primers Enzyme Inhibitors--pharmacology Interferon-beta--biosynthesis Membrane Glycoproteins--physiology Mice NF-kappa B--metabolism Nitric Oxide--biosynthesis Nitric Oxide Synthase Type II--antagonists & inhibitors Osteoclasts--enzymology RANK Ligand Receptor Activator of Nuclear Factor-kappa B Reverse Transcriptase Polymerase Chain Reaction