TY  - GEN
AU  - Huang,Yong
AU  - Okochi,Hideaki
AU  - May,Barnaby C H
AU  - Legname,Giuseppe
AU  - Prusiner,Stanley B
AU  - Benet,Leslie Z
AU  - Guglielmo,B Joseph
AU  - Lin,Emil T
TI  - Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein
SN  - 0090-9556
PY  - 2006///0831
KW  - ATP Binding Cassette Transporter, Subfamily B
KW  - genetics
KW  - ATP-Binding Cassette Transporters
KW  - Animals
KW  - Antimalarials
KW  - pharmacokinetics
KW  - Biotransformation
KW  - Blood-Brain Barrier
KW  - metabolism
KW  - Brain
KW  - Cell Line
KW  - Cytochrome P-450 CYP3A
KW  - Cytochrome P-450 Enzyme Inhibitors
KW  - Cytochrome P-450 Enzyme System
KW  - Dogs
KW  - Enzyme Inhibitors
KW  - pharmacology
KW  - Humans
KW  - Ketoconazole
KW  - Liver
KW  - Male
KW  - Mice
KW  - Mice, Knockout
KW  - Microsomes, Liver
KW  - Quinacrine
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Recombinant Proteins
KW  - ATP-Binding Cassette Sub-Family B Member 4
N1  - Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
UR  - https://doi.org/10.1124/dmd.105.008664
ER  -