Huang, Yong <br/><br/>
Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  Jul 2006 
 - 1136-44 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural 
<br/><br/><label>ISSN: </label>0090-9556 
<br/><br/><label>Standard No.: </label>10.1124/dmd.105.008664  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>ATP Binding Cassette Transporter, Subfamily B--genetics<br/>ATP-Binding Cassette Transporters--genetics<br/>Animals<br/>Antimalarials--pharmacokinetics<br/>Biotransformation<br/>Blood-Brain Barrier--metabolism<br/>Brain--metabolism<br/>Cell Line<br/>Cytochrome P-450 CYP3A<br/>Cytochrome P-450 Enzyme Inhibitors<br/>Cytochrome P-450 Enzyme System--genetics<br/>Dogs<br/>Enzyme Inhibitors--pharmacology<br/>Humans<br/>Ketoconazole--pharmacology<br/>Liver--metabolism<br/>Male<br/>Mice<br/>Mice, Knockout<br/>Microsomes, Liver<br/>Quinacrine--pharmacokinetics<br/>Rats<br/>Rats, Sprague-Dawley<br/>Recombinant Proteins--metabolism<br/>ATP-Binding Cassette Sub-Family B Member 4