TY - GEN AU - Kim,Ki Won AU - Wang,Zhulun AU - Busby,James AU - Tsuruda,Trace AU - Chen,Michelle AU - Hale,Clarence AU - Castro,VĂ­ctor M AU - Svensson,Stefan AU - Nybo,Rebecca AU - Xiong,Fei AU - Wang,Minghan TI - The role of tyrosine 177 in human 11beta-hydroxysteroid dehydrogenase type 1 in substrate and inhibitor binding: an unlikely hydrogen bond donor for the substrate SN - 0006-3002 PY - 2006///0620 KW - 11-beta-Hydroxysteroid Dehydrogenase Type 1 KW - antagonists & inhibitors KW - Amino Acid Sequence KW - Amino Acid Substitution KW - Animals KW - Binding Sites KW - CHO Cells KW - Carbenoxolone KW - pharmacology KW - Cortisone KW - metabolism KW - Cricetinae KW - Cricetulus KW - Glycyrrhetinic Acid KW - Humans KW - Hydrocortisone KW - Hydrogen Bonding KW - Kinetics KW - Models, Molecular KW - Substrate Specificity KW - Tyrosine KW - chemistry N1 - Publication Type: Journal Article UR - https://doi.org/10.1016/j.bbapap.2006.02.008 ER -