Kim, Young-Rim

Heavy and light chain variable single domains of an anti-DNA binding antibody hydrolyze both double- and single-stranded DNAs without sequence specificity. [electronic resource] - The Journal of biological chemistry Jun 2006 - 15287-95 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M600937200 doi


Amino Acid Substitution
Animals
Antibodies, Antinuclear--chemistry
Base Sequence
Crystallography, X-Ray
DNA--genetics
DNA, Single-Stranded--genetics
Humans
Hydrolysis
Immunoglobulin Fragments--chemistry
Immunoglobulin Heavy Chains--chemistry
Immunoglobulin Light Chains--chemistry
In Vitro Techniques
Kinetics
Mice
Mice, Inbred MRL lpr
Models, Molecular
Mutagenesis, Site-Directed
Protein Conformation
Protein Structure, Tertiary
Recombinant Proteins--chemistry