Heavy and light chain variable single domains of an anti-DNA binding antibody hydrolyze both double- and single-stranded DNAs without sequence specificity. [electronic resource]
- The Journal of biological chemistry Jun 2006
- 15287-95 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M600937200 doi
Amino Acid Substitution Animals Antibodies, Antinuclear--chemistry Base Sequence Crystallography, X-Ray DNA--genetics DNA, Single-Stranded--genetics Humans Hydrolysis Immunoglobulin Fragments--chemistry Immunoglobulin Heavy Chains--chemistry Immunoglobulin Light Chains--chemistry In Vitro Techniques Kinetics Mice Mice, Inbred MRL lpr Models, Molecular Mutagenesis, Site-Directed Protein Conformation Protein Structure, Tertiary Recombinant Proteins--chemistry