TY  - GEN
AU  - Zhang,Guang-Sen
AU  - Liu,Ding-Sheng
AU  - Dai,Chong-Wen
AU  - Li,Rui-Juan
TI  - Antitumor effects of celecoxib on K562 leukemia cells are mediated by cell-cycle arrest, caspase-3 activation, and downregulation of Cox-2 expression and are synergistic with hydroxyurea or imatinib
SN  - 0361-8609
PY  - 2006///0522
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Antineoplastic Combined Chemotherapy Protocols
KW  - Apoptosis
KW  - drug effects
KW  - Benzamides
KW  - Bone Marrow Cells
KW  - enzymology
KW  - Caspase 3
KW  - Caspase Inhibitors
KW  - Caspases
KW  - metabolism
KW  - Celecoxib
KW  - Cyclin D1
KW  - Cyclin E
KW  - Cyclin-Dependent Kinase Inhibitor p16
KW  - Cyclin-Dependent Kinase Inhibitor p27
KW  - Cyclooxygenase 2
KW  - biosynthesis
KW  - Cyclooxygenase Inhibitors
KW  - Dose-Response Relationship, Drug
KW  - Down-Regulation
KW  - Drug Synergism
KW  - Enzyme Activation
KW  - Enzyme Inhibitors
KW  - G1 Phase
KW  - Gene Expression Regulation, Enzymologic
KW  - Gene Expression Regulation, Leukemic
KW  - Humans
KW  - Hydroxyurea
KW  - Imatinib Mesylate
KW  - Interleukin-1
KW  - Intracellular Signaling Peptides and Proteins
KW  - K562 Cells
KW  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive
KW  - drug therapy
KW  - Membrane Proteins
KW  - antagonists & inhibitors
KW  - Piperazines
KW  - Pyrazoles
KW  - Pyrimidines
KW  - S Phase
KW  - Sulfonamides
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1002/ajh.20542
ER  -