Zhang, Guang-Sen <br/><br/>
Antitumor effects of celecoxib on K562 leukemia cells are mediated by cell-cycle arrest, caspase-3 activation, and downregulation of Cox-2 expression and are synergistic with hydroxyurea or imatinib.  [electronic resource] 

 -  American journal of hematology  Apr 2006 
 - 242-55 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0361-8609 
<br/><br/><label>Standard No.: </label>10.1002/ajh.20542  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antineoplastic Agents--pharmacology<br/>Antineoplastic Combined Chemotherapy Protocols--pharmacology<br/>Apoptosis--drug effects<br/>Benzamides<br/>Bone Marrow Cells--enzymology<br/>Caspase 3<br/>Caspase Inhibitors<br/>Caspases--metabolism<br/>Celecoxib<br/>Cyclin D1--metabolism<br/>Cyclin E--metabolism<br/>Cyclin-Dependent Kinase Inhibitor p16--metabolism<br/>Cyclin-Dependent Kinase Inhibitor p27<br/>Cyclooxygenase 2--biosynthesis<br/>Cyclooxygenase Inhibitors--pharmacology<br/>Dose-Response Relationship, Drug<br/>Down-Regulation--drug effects<br/>Drug Synergism<br/>Enzyme Activation--drug effects<br/>Enzyme Inhibitors--pharmacology<br/>G1 Phase--drug effects<br/>Gene Expression Regulation, Enzymologic--drug effects<br/>Gene Expression Regulation, Leukemic--drug effects<br/>Humans<br/>Hydroxyurea--pharmacology<br/>Imatinib Mesylate<br/>Interleukin-1--pharmacology<br/>Intracellular Signaling Peptides and Proteins--metabolism<br/>K562 Cells<br/>Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy<br/>Membrane Proteins--antagonists & inhibitors<br/>Piperazines--pharmacology<br/>Pyrazoles--pharmacology<br/>Pyrimidines--pharmacology<br/>S Phase--drug effects<br/>Sulfonamides--pharmacology