Kojima, Kensuke <br/><br/>
Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia.  [electronic resource] 

 -  Blood  Aug 2006 
 - 993-1000 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0006-4971 
<br/><br/><label>Standard No.: </label>10.1182/blood-2005-12-5148  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Apoptosis--drug effects<br/>Ataxia Telangiectasia Mutated Proteins<br/>Cell Cycle Proteins--physiology<br/>Cells, Cultured<br/>DNA-Binding Proteins--physiology<br/>Drug Resistance, Neoplasm<br/>Drug Synergism<br/>Drug Therapy, Combination<br/>Humans<br/>Imidazoles--pharmacology<br/>Leukemia, Lymphocytic, Chronic, B-Cell--drug therapy<br/>Mutation<br/>Piperazines--pharmacology<br/>Protein Serine-Threonine Kinases--physiology<br/>Proto-Oncogene Proteins c-mdm2--antagonists & inhibitors<br/>Transcription, Genetic<br/>Tumor Suppressor Protein p53--genetics<br/>Tumor Suppressor Proteins--physiology<br/>Vidarabine--analogs & derivatives