A single point mutation in the low-density lipoprotein receptor switches the degradation of its mature protein from the proteasome to the lysosome. [electronic resource]
- The international journal of biochemistry & cell biology 2006
- 1340-51 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1357-2725
10.1016/j.biocel.2006.01.014 doi
Acetylcysteine--analogs & derivatives Animals Binding, Competitive--drug effects Biological Transport--drug effects CHO Cells COS Cells Chlorocebus aethiops Cricetinae Cricetulus Cysteine Proteinase Inhibitors--pharmacology Humans Lipoproteins, LDL--metabolism Lysosomes--metabolism Mutant Proteins--genetics Point Mutation Proteasome Endopeptidase Complex--metabolism Proteasome Inhibitors Protein Processing, Post-Translational Receptors, LDL--genetics Signal Transduction--drug effects