Martín de Llano, José Javier

A single point mutation in the low-density lipoprotein receptor switches the degradation of its mature protein from the proteasome to the lysosome. [electronic resource] - The international journal of biochemistry & cell biology 2006 - 1340-51 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1357-2725

10.1016/j.biocel.2006.01.014 doi


Acetylcysteine--analogs & derivatives
Animals
Binding, Competitive--drug effects
Biological Transport--drug effects
CHO Cells
COS Cells
Chlorocebus aethiops
Cricetinae
Cricetulus
Cysteine Proteinase Inhibitors--pharmacology
Humans
Lipoproteins, LDL--metabolism
Lysosomes--metabolism
Mutant Proteins--genetics
Point Mutation
Proteasome Endopeptidase Complex--metabolism
Proteasome Inhibitors
Protein Processing, Post-Translational
Receptors, LDL--genetics
Signal Transduction--drug effects