Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia. [electronic resource]
- The Journal of biological chemistry Apr 2006
- 10745-51 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
0021-9258
10.1074/jbc.M510924200 doi
Animals Apoptosis Blotting, Western CCAAT-Enhancer-Binding Proteins--biosynthesis Cell Cycle Cell Differentiation Cell Line Cell Proliferation Cell Survival DNA--metabolism DNA Fragmentation DNA-Binding Proteins--genetics Gene Expression Regulation Genetic Vectors Granulocyte Colony-Stimulating Factor--metabolism Granulocytes--metabolism Interleukin-3--metabolism Mice Mutation Myeloid Cells--metabolism Neutropenia--congenital Protein Structure, Tertiary Proto-Oncogene Proteins c-bcl-2--metabolism RNA, Messenger--metabolism Signal Transduction Time Factors Transcription Factors--genetics Transcription, Genetic Transfection Up-Regulation Zinc Fingers