TY  - GEN
AU  - Berry,Mike A
AU  - Hargadon,Beverley
AU  - Shelley,Maria
AU  - Parker,Debbie
AU  - Shaw,Dominick E
AU  - Green,Ruth H
AU  - Bradding,Peter
AU  - Brightling,Christopher E
AU  - Wardlaw,Andrew J
AU  - Pavord,Ian D
TI  - Evidence of a role of tumor necrosis factor alpha in refractory asthma
SN  - 1533-4406
PY  - 2006///0221
KW  - ADAM Proteins
KW  - biosynthesis
KW  - ADAM17 Protein
KW  - Adolescent
KW  - Adult
KW  - Aged
KW  - Asthma
KW  - drug therapy
KW  - Biomarkers
KW  - metabolism
KW  - Bronchial Hyperreactivity
KW  - Case-Control Studies
KW  - Cross-Over Studies
KW  - Double-Blind Method
KW  - Etanercept
KW  - Female
KW  - Forced Expiratory Volume
KW  - drug effects
KW  - Humans
KW  - Immunoglobulin G
KW  - therapeutic use
KW  - Immunologic Factors
KW  - Male
KW  - Methacholine Chloride
KW  - Middle Aged
KW  - Monocytes
KW  - Pilot Projects
KW  - Receptors, Tumor Necrosis Factor
KW  - Receptors, Tumor Necrosis Factor, Type I
KW  - Treatment Outcome
KW  - Tumor Necrosis Factor-alpha
KW  - antagonists & inhibitors
KW  - Up-Regulation
N1  - Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1056/NEJMoa050580
ER  -