TY - GEN AU - Sentinelli,F AU - Filippi,E AU - Cavallo,M G AU - Romeo,S AU - Fanelli,M AU - Baroni,M G TI - The G972R variant of the insulin receptor substrate-1 gene impairs insulin signaling and cell differentiation in 3T3L1 adipocytes; treatment with a PPARgamma agonist restores normal cell signaling and differentiation SN - 0022-0795 PY - 2006///0404 KW - 3T3 Cells KW - Adipocytes KW - drug effects KW - Animals KW - Cell Differentiation KW - Humans KW - Hypoglycemic Agents KW - pharmacology KW - Insulin KW - metabolism KW - Insulin Receptor Substrate Proteins KW - Mice KW - Mitogen-Activated Protein Kinases KW - Mutation KW - PPAR gamma KW - agonists KW - Phosphatidylinositol 3-Kinases KW - Phosphoproteins KW - genetics KW - Phosphorylation KW - Pioglitazone KW - Serine KW - Signal Transduction KW - Thiazolidinediones KW - Threonine KW - Transfection KW - Tyrosine N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1677/joe.1.06290 ER -