Sentinelli, F <br/><br/>
The G972R variant of the insulin receptor substrate-1 gene impairs insulin signaling and cell differentiation in 3T3L1 adipocytes; treatment with a PPARgamma agonist restores normal cell signaling and differentiation.  [electronic resource] 

 -  The Journal of endocrinology  Feb 2006 
 - 271-85 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0022-0795 
<br/><br/><label>Standard No.: </label>10.1677/joe.1.06290  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>3T3 Cells<br/>Adipocytes--drug effects<br/>Animals<br/>Cell Differentiation--drug effects<br/>Humans<br/>Hypoglycemic Agents--pharmacology<br/>Insulin--metabolism<br/>Insulin Receptor Substrate Proteins<br/>Mice<br/>Mitogen-Activated Protein Kinases--metabolism<br/>Mutation<br/>PPAR gamma--agonists<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Phosphoproteins--genetics<br/>Phosphorylation<br/>Pioglitazone<br/>Serine--metabolism<br/>Signal Transduction--drug effects<br/>Thiazolidinediones--pharmacology<br/>Threonine--metabolism<br/>Transfection<br/>Tyrosine--metabolism