TY  - GEN
AU  - Park,Hee-Sung
AU  - Nam,Sung-Hun
AU  - Lee,Jin Kak
AU  - Yoon,Chang No
AU  - Mannervik,Bengt
AU  - Benkovic,Stephen J
AU  - Kim,Hak-Sung
TI  - Design and evolution of new catalytic activity with an existing protein scaffold
SN  - 1095-9203
PY  - 2006///0203
KW  - Amino Acid Sequence
KW  - Binding Sites
KW  - Catalysis
KW  - Catalytic Domain
KW  - Cefotaxime
KW  - metabolism
KW  - Directed Molecular Evolution
KW  - Drug Resistance, Bacterial
KW  - Escherichia coli
KW  - drug effects
KW  - Evolution, Molecular
KW  - Humans
KW  - Hydrophobic and Hydrophilic Interactions
KW  - Iron
KW  - Kinetics
KW  - Metals
KW  - Models, Molecular
KW  - Molecular Sequence Data
KW  - Point Mutation
KW  - Protein Conformation
KW  - Protein Engineering
KW  - Protein Folding
KW  - Protein Structure, Secondary
KW  - Protein Structure, Tertiary
KW  - Recombinant Fusion Proteins
KW  - Substrate Specificity
KW  - Thiolester Hydrolases
KW  - chemistry
KW  - Zinc
KW  - beta-Lactamases
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1126/science.1118953
ER  -