Park, Hee-Sung <br/><br/>
Design and evolution of new catalytic activity with an existing protein scaffold.  [electronic resource] 

 -  Science (New York, N.Y.)  Jan 2006 
 - 535-8 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1095-9203 
<br/><br/><label>Standard No.: </label>10.1126/science.1118953  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Sequence<br/>Binding Sites<br/>Catalysis<br/>Catalytic Domain<br/>Cefotaxime--metabolism<br/>Directed Molecular Evolution<br/>Drug Resistance, Bacterial<br/>Escherichia coli--drug effects<br/>Evolution, Molecular<br/>Humans<br/>Hydrophobic and Hydrophilic Interactions<br/>Iron--metabolism<br/>Kinetics<br/>Metals--metabolism<br/>Models, Molecular<br/>Molecular Sequence Data<br/>Point Mutation<br/>Protein Conformation<br/>Protein Engineering<br/>Protein Folding<br/>Protein Structure, Secondary<br/>Protein Structure, Tertiary<br/>Recombinant Fusion Proteins--metabolism<br/>Substrate Specificity<br/>Thiolester Hydrolases--chemistry<br/>Zinc--metabolism<br/>beta-Lactamases--chemistry