Gallagher, R E <br/><br/>
Relapse of acute promyelocytic leukemia with PML-RARalpha mutant subclones independent of proximate all-trans retinoic acid selection pressure.  [electronic resource] 

 -  Leukemia  Apr 2006 
 - 556-62 p.  digital 
<br/><br/> Publication Type: Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural 
<br/><br/><label>ISSN: </label>0887-6924 
<br/><br/><label>Standard No.: </label>10.1038/sj.leu.2404118  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adult<br/>Antineoplastic Combined Chemotherapy Protocols--therapeutic use<br/>Binding Sites<br/>Cell Lineage<br/>Clone Cells<br/>Drug Resistance, Neoplasm--genetics<br/>Epigenesis, Genetic<br/>Humans<br/>Leukemia, Promyelocytic, Acute--drug therapy<br/>Mutation<br/>Neoplasm Proteins--drug effects<br/>Oncogene Proteins, Fusion--drug effects<br/>Recurrence<br/>Remission Induction<br/>Reverse Transcriptase Polymerase Chain Reaction<br/>Sensitivity and Specificity<br/>Structure-Activity Relationship<br/>Tretinoin--adverse effects