TY  - GEN
AU  - Salvatorelli,Emanuela
AU  - Guarnieri,Simone
AU  - Menna,Pierantonio
AU  - Liberi,Giovanni
AU  - Calafiore,Antonio M
AU  - Mariggiò,Maria A
AU  - Mordente,Alvaro
AU  - Gianni,Luca
AU  - Minotti,Giorgio
TI  - Defective one- or two-electron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition
SN  - 0021-9258
PY  - 2006///0613
KW  - Aconitate Hydratase
KW  - metabolism
KW  - Adenosine Triphosphatases
KW  - chemistry
KW  - Aged
KW  - Antibiotics, Antineoplastic
KW  - pharmacology
KW  - Antineoplastic Agents
KW  - Area Under Curve
KW  - Cell Line, Tumor
KW  - Cell Membrane
KW  - Cell-Free System
KW  - Cells, Cultured
KW  - Cytoplasm
KW  - Dose-Response Relationship, Drug
KW  - Electrons
KW  - Epirubicin
KW  - Female
KW  - Fluorescent Dyes
KW  - Humans
KW  - Hydrogen Peroxide
KW  - Inhibitory Concentration 50
KW  - Kinetics
KW  - Macrolides
KW  - Male
KW  - Microscopy, Confocal
KW  - Microscopy, Fluorescence
KW  - Middle Aged
KW  - Mitochondria
KW  - Models, Chemical
KW  - Myocardium
KW  - Oxidation-Reduction
KW  - Oxygen
KW  - Protein Biosynthesis
KW  - Protons
KW  - Reactive Oxygen Species
KW  - Time Factors
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1074/jbc.M508343200
ER  -