Salvatorelli, Emanuela <br/><br/>
Defective one- or two-electron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition.  [electronic resource] 

 -  The Journal of biological chemistry  Apr 2006 
 - 10990-1001 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0021-9258 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M508343200  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aconitate Hydratase--metabolism<br/>Adenosine Triphosphatases--chemistry<br/>Aged<br/>Antibiotics, Antineoplastic--pharmacology<br/>Antineoplastic Agents--pharmacology<br/>Area Under Curve<br/>Cell Line, Tumor<br/>Cell Membrane--metabolism<br/>Cell-Free System<br/>Cells, Cultured<br/>Cytoplasm--metabolism<br/>Dose-Response Relationship, Drug<br/>Electrons<br/>Epirubicin--chemistry<br/>Female<br/>Fluorescent Dyes--pharmacology<br/>Humans<br/>Hydrogen Peroxide--chemistry<br/>Inhibitory Concentration 50<br/>Kinetics<br/>Macrolides--chemistry<br/>Male<br/>Microscopy, Confocal<br/>Microscopy, Fluorescence<br/>Middle Aged<br/>Mitochondria--metabolism<br/>Models, Chemical<br/>Myocardium--metabolism<br/>Oxidation-Reduction<br/>Oxygen--metabolism<br/>Protein Biosynthesis<br/>Protons<br/>Reactive Oxygen Species<br/>Time Factors