A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation derived from the effects of terfenadine, cisapride and E-4031 in the conscious chronic av node--ablated, His bundle-paced dog. [electronic resource]
- Journal of pharmacological and toxicological methods
- 1-10 p. digital
Publication Type: Journal Article
1056-8719
10.1016/j.vascn.2005.02.003 doi
Animals Anti-Arrhythmia Agents--blood Atrioventricular Node--surgery Bundle of His--surgery Cardiac Pacing, Artificial Catheter Ablation Cisapride--blood Dogs Dose-Response Relationship, Drug Drug Evaluation, Preclinical--methods Electrocardiography--drug effects Gastrointestinal Agents--blood Histamine H1 Antagonists--blood Ion Channels--antagonists & inhibitors Long QT Syndrome--etiology Male Models, Animal Models, Biological Piperidines--blood Pyridines--blood Terfenadine--blood