Mühlhausen, Ute

Synthesis of 131I-labeled glucose-conjugated inhibitors of O6-methylguanine-DNA methyltransferase (MGMT) and comparison with nonconjugated inhibitors as potential tools for in vivo MGMT imaging. [electronic resource] - Journal of medicinal chemistry Jan 2006 - 263-72 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0022-2623

10.1021/jm050588q doi


Animals
Antineoplastic Agents--chemical synthesis
Enzyme Inhibitors--chemical synthesis
Glucose--chemistry
Guanine--analogs & derivatives
HeLa Cells
Humans
In Vitro Techniques
Iodine Isotopes
Mice
Mice, Nude
Molecular Structure
O(6)-Methylguanine-DNA Methyltransferase--antagonists & inhibitors
Structure-Activity Relationship
Time Factors
Transplantation, Heterologous
Xenograft Model Antitumor Assays