Synthesis of 131I-labeled glucose-conjugated inhibitors of O6-methylguanine-DNA methyltransferase (MGMT) and comparison with nonconjugated inhibitors as potential tools for in vivo MGMT imaging. [electronic resource]
- Journal of medicinal chemistry Jan 2006
- 263-72 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0022-2623
10.1021/jm050588q doi
Animals Antineoplastic Agents--chemical synthesis Enzyme Inhibitors--chemical synthesis Glucose--chemistry Guanine--analogs & derivatives HeLa Cells Humans In Vitro Techniques Iodine Isotopes Mice Mice, Nude Molecular Structure O(6)-Methylguanine-DNA Methyltransferase--antagonists & inhibitors Structure-Activity Relationship Time Factors Transplantation, Heterologous Xenograft Model Antitumor Assays