TY  - GEN
AU  - Napper,Andrew D
AU  - Hixon,Jeffrey
AU  - McDonagh,Thomas
AU  - Keavey,Kenneth
AU  - Pons,Jean-Francois
AU  - Barker,Jonathan
AU  - Yau,Wei Tsung
AU  - Amouzegh,Patricia
AU  - Flegg,Adam
AU  - Hamelin,Estelle
AU  - Thomas,Russell J
AU  - Kates,Michael
AU  - Jones,Stephen
AU  - Navia,Manuel A
AU  - Saunders,Jeffrey O
AU  - DiStefano,Peter S
AU  - Curtis,Rory
TI  - Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1
SN  - 0022-2623
PY  - 2006///0207
KW  - Animals
KW  - Biological Availability
KW  - CHO Cells
KW  - Carbazoles
KW  - chemical synthesis
KW  - Cell Membrane Permeability
KW  - Cricetinae
KW  - Cricetulus
KW  - Drug Stability
KW  - Fluorometry
KW  - Histone Deacetylase Inhibitors
KW  - Histone Deacetylases
KW  - chemistry
KW  - Humans
KW  - In Vitro Techniques
KW  - Indoles
KW  - Kinetics
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Microsomes, Liver
KW  - metabolism
KW  - NAD
KW  - NAD+ Nucleosidase
KW  - Niacinamide
KW  - Rats
KW  - Recombinant Proteins
KW  - antagonists & inhibitors
KW  - Sirtuin 1
KW  - Sirtuins
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm050522v
ER  -