Napper, Andrew D <br/><br/>
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.  [electronic resource] 

 -  Journal of medicinal chemistry  Dec 2005 
 - 8045-54 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm050522v  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Biological Availability<br/>CHO Cells<br/>Carbazoles--chemical synthesis<br/>Cell Membrane Permeability<br/>Cricetinae<br/>Cricetulus<br/>Drug Stability<br/>Fluorometry<br/>Histone Deacetylase Inhibitors<br/>Histone Deacetylases--chemistry<br/>Humans<br/>In Vitro Techniques<br/>Indoles--chemical synthesis<br/>Kinetics<br/>Mice<br/>Mice, Inbred C57BL<br/>Microsomes, Liver--metabolism<br/>NAD--chemistry<br/>NAD+ Nucleosidase--chemistry<br/>Niacinamide--chemistry<br/>Rats<br/>Recombinant Proteins--antagonists & inhibitors<br/>Sirtuin 1<br/>Sirtuins--antagonists & inhibitors<br/>Stereoisomerism<br/>Structure-Activity Relationship