Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. [electronic resource]
- Gene therapy Feb 2006
- 206-15 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0969-7128
10.1038/sj.gt.3302640 doi
Adenocarcinoma--pathology Adenoviridae--genetics Animals Antiviral Agents--therapeutic use Brain Neoplasms--pathology Breast Neoplasms--pathology Cell Death Cell Hypoxia Combined Modality Therapy Early Growth Response Protein 1--genetics Erythropoietin--genetics Ganciclovir--therapeutic use Gene Expression Regulation, Neoplastic Genes, Switch Genes, Transgenic, Suicide Genetic Engineering--methods Genetic Therapy--methods Genetic Vectors--administration & dosage Glioma--pathology Humans Mice Mice, Nude Neoplasms--pathology Oncolytic Virotherapy--methods Promoter Regions, Genetic Simplexvirus--enzymology Thymidine Kinase--biosynthesis Tumor Cells, Cultured