Pharmacological efficacy of CPU 86017 on hypoxic pulmonary hypertension in rats: mediated by direct inhibition of calcium channels and antioxidant action, but indirect effects on the ET-1 pathway. [electronic resource]
- Journal of cardiovascular pharmacology Dec 2005
- 727-34 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0160-2446
10.1097/01.fjc.0000184470.58047.79 doi
Animals Antioxidants--therapeutic use Berberine--analogs & derivatives Calcium Channel Blockers--therapeutic use Calcium Channels, L-Type--drug effects Endothelin-1--antagonists & inhibitors Hypertension, Pulmonary--drug therapy Hypertrophy, Right Ventricular--drug therapy Hypoxia--complications Male Malondialdehyde--analysis Nitric Oxide--biosynthesis Nitric Oxide Synthase--metabolism Oxidative Stress--drug effects Pulmonary Artery--pathology Rats Rats, Sprague-Dawley