TY  - GEN
AU  - Falgueyret,Jean-Pierre
AU  - Desmarais,Sylvie
AU  - Oballa,Renata
AU  - Black,W Cameron
AU  - Cromlish,Wanda
AU  - Khougaz,Karine
AU  - Lamontagne,Sonia
AU  - Massé,Frederic
AU  - Riendeau,Denis
AU  - Toulmond,Sylvie
AU  - Percival,M David
TI  - Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity
SN  - 0022-2623
PY  - 2006///0209
KW  - Animals
KW  - Antigen Presentation
KW  - drug effects
KW  - Autoradiography
KW  - Benzamides
KW  - chemistry
KW  - Bone Density Conservation Agents
KW  - Cathepsin B
KW  - antagonists & inhibitors
KW  - Cathepsin K
KW  - Cathepsin L
KW  - Cathepsins
KW  - Cell Line
KW  - Cysteine Endopeptidases
KW  - Female
KW  - Humans
KW  - Lysosomes
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Morpholines
KW  - Piperazines
KW  - Rabbits
KW  - Rats
KW  - Structure-Activity Relationship
KW  - Thiazoles
KW  - Tissue Distribution
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm0504961
ER  -