Pastorino, John G

Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. [electronic resource] - Cancer research Nov 2005 - 10545-54 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

0008-5472

10.1158/0008-5472.CAN-05-1925 doi


Calcium Channels--metabolism
Doxorubicin--pharmacology
Drug Synergism
Enzyme Activation
Glycogen Synthase Kinase 3--metabolism
Glycogen Synthase Kinase 3 beta
HeLa Cells
Hexokinase--antagonists & inhibitors
Humans
Mitochondria--metabolism
Paclitaxel--pharmacology
Peptide Fragments--pharmacology
Phosphorylation
Proto-Oncogene Proteins c-akt--antagonists & inhibitors