Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. [electronic resource]
- The Journal of clinical investigation Dec 2005
- 3484-93 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
0021-9738
10.1172/JCI24059 doi
Agouti-Related Protein Alleles Animals Blood Glucose--metabolism Body Composition Body Weight Cold Temperature DNA, Complementary--metabolism Diabetes Mellitus--genetics Female Fertility Gene Expression Regulation Genetic Therapy--methods Genotype Glucose--metabolism Homeostasis Homozygote Hypothalamus--pathology In Situ Hybridization Infertility--genetics Infertility, Female--therapy Infertility, Male--therapy Insulin--metabolism Intercellular Signaling Peptides and Proteins Male Mice Mice, Transgenic Neurons--metabolism Neuropeptide Y--genetics Obesity--genetics Peptides--chemistry Phenotype Phosphopyruvate Hydratase--genetics Polymerase Chain Reaction Pro-Opiomelanocortin--genetics Promoter Regions, Genetic Protein Isoforms Proteins--genetics Rats Receptors, Cell Surface--genetics Receptors, Leptin Signal Transduction Synapsins--genetics Time Factors Tissue Distribution Transgenes