Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. [electronic resource]
- The Journal of biological chemistry Jan 2006
- 2012-23 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M505055200 doi
Adrenergic Uptake Inhibitors--pharmacology Amino Acid Sequence Animals Antidepressive Agents--pharmacology Binding Sites Binding, Competitive Blotting, Western Cadmium--chemistry Cell Line Cell Membrane--metabolism Citalopram--pharmacology Clomipramine--pharmacology Cocaine--analogs & derivatives Cysteine--chemistry Dopamine Uptake Inhibitors--pharmacology Fluoxetine--analogs & derivatives HeLa Cells Humans Immunoprecipitation Isoleucine--chemistry Kinetics LLC-PK1 Cells Mazindol--pharmacology Methionine--chemistry Mice Models, Chemical Molecular Sequence Data Mutation N-Methyl-3,4-methylenedioxyamphetamine--chemistry Nomifensine--pharmacology Protein Binding Protein Structure, Tertiary Protein Transport Radiopharmaceuticals--pharmacology Receptors, Serotonin--chemistry Serotonin--chemistry Selective Serotonin Reuptake Inhibitors--pharmacology Species Specificity Stereoisomerism Substrate Specificity Tyrosine--chemistry