Michael addition reactions between chiral equivalents of a nucleophilic glycine and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general method for efficient preparation of beta-substituted pyroglutamic acids. Case of topographically controlled stereoselectivity. [electronic resource]
- Journal of the American Chemical Society Nov 2005
- 15296-303 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0002-7863
10.1021/ja0535561 doi
Catalysis Glycine--chemistry Kinetics Models, Chemical Molecular Structure Nickel--chemistry Oxazolidinones--chemistry Pyrrolidonecarboxylic Acid--chemistry Schiff Bases--chemistry Spectrometry, Mass, Fast Atom Bombardment Stereoisomerism