Blocking tumor cell migration and invasion with biphenyl isoxazole derivative KRIBB3, a synthetic molecule that inhibits Hsp27 phosphorylation. [electronic resource]
- The Journal of biological chemistry Dec 2005
- 41439-48 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M507209200 doi
Amino Acid Sequence Anisoles--chemistry Antineoplastic Agents--pharmacology Blotting, Western Bromides--chemistry Cell Line, Tumor Cell Membrane--metabolism Cell Movement Chromatography, Affinity Crk-Associated Substrate Protein--metabolism DNA, Complementary--metabolism Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Enzyme Activation Enzyme Inhibitors--pharmacology Focal Adhesion Protein-Tyrosine Kinases--metabolism HSP27 Heat-Shock Proteins Heat-Shock Proteins--antagonists & inhibitors Humans Inhibitory Concentration 50 Intracellular Signaling Peptides and Proteins Isoxazoles--chemistry Models, Chemical Molecular Chaperones Molecular Sequence Data Neoplasm Invasiveness Neoplasm Proteins--antagonists & inhibitors Neoplasms--drug therapy Phosphatidylinositol 3-Kinases--metabolism Phosphorylation Protein Binding Protein Kinase C--metabolism Protein Serine-Threonine Kinases--metabolism Protein Structure, Tertiary RNA, Small Interfering--chemistry Time Factors Transfection