Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis. [electronic resource]
- Arthritis research & therapy 2005
- R1034-45 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1478-6362
10.1186/ar1779 doi
Animals Arthritis, Experimental--drug therapy Bone and Bones--drug effects Cyclooxygenase 2--metabolism Cytokines--biosynthesis Disease Models, Animal Drug Evaluation Gene Expression Profiling Glycoproteins--blood I-kappa B Proteins--blood Inflammation Mediators--blood JNK Mitogen-Activated Protein Kinases--antagonists & inhibitors Male Mice Mice, Inbred DBA NF-KappaB Inhibitor alpha NF-kappa B--antagonists & inhibitors Nitric Oxide Synthase Type II--metabolism Osteoclasts--drug effects Osteolysis--etiology Osteoprotegerin Protein Transport--drug effects Proto-Oncogene Proteins c-jun--blood RNA, Messenger--biosynthesis Receptors, Cytoplasmic and Nuclear--blood Receptors, Tumor Necrosis Factor--blood Transcription Factor AP-1--metabolism Transcription, Genetic--drug effects Vasoactive Intestinal Peptide--pharmacology