TY  - GEN
AU  - Atack,John R
AU  - Wafford,Keith A
AU  - Tye,Spencer J
AU  - Cook,Susan M
AU  - Sohal,Bindi
AU  - Pike,Andrew
AU  - Sur,Cyrille
AU  - Melillo,David
AU  - Bristow,Linda
AU  - Bromidge,Fran
AU  - Ragan,Ian
AU  - Kerby,Julie
AU  - Street,Les
AU  - Carling,Robert
AU  - Castro,José L
AU  - Whiting,Paul
AU  - Dawson,Gerard R
AU  - McKernan,Ruth M
TI  - TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates
SN  - 0022-3565
PY  - 2006///0331
KW  - Acoustic Stimulation
KW  - Adrenergic alpha-1 Receptor Antagonists
KW  - Adrenergic alpha-Agonists
KW  - pharmacology
KW  - Animals
KW  - Anti-Anxiety Agents
KW  - Anticonvulsants
KW  - Autoradiography
KW  - Conditioning, Operant
KW  - drug effects
KW  - Convulsants
KW  - Drinking
KW  - Emotions
KW  - Fear
KW  - Flumazenil
KW  - metabolism
KW  - GABA Modulators
KW  - GABA-A Receptor Agonists
KW  - Humans
KW  - Male
KW  - Mice
KW  - Pentylenetetrazole
KW  - antagonists & inhibitors
KW  - Postural Balance
KW  - Protein Binding
KW  - Pyridazines
KW  - Radioligand Assay
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Receptors, GABA-A
KW  - Recombinant Proteins
KW  - Reflex, Startle
KW  - Saimiri
KW  - Substance Withdrawal Syndrome
KW  - psychology
KW  - Triazoles
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1124/jpet.105.089920
ER  -