Atack, John R <br/><br/>
TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.  [electronic resource] 

 -  The Journal of pharmacology and experimental therapeutics  Jan 2006 
 - 410-22 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0022-3565 
<br/><br/><label>Standard No.: </label>10.1124/jpet.105.089920  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Acoustic Stimulation<br/>Adrenergic alpha-1 Receptor Antagonists<br/>Adrenergic alpha-Agonists--pharmacology<br/>Animals<br/>Anti-Anxiety Agents<br/>Anticonvulsants--pharmacology<br/>Autoradiography<br/>Conditioning, Operant--drug effects<br/>Convulsants--pharmacology<br/>Drinking--drug effects<br/>Emotions--drug effects<br/>Fear--drug effects<br/>Flumazenil--metabolism<br/>GABA Modulators--metabolism<br/>GABA-A Receptor Agonists<br/>Humans<br/>Male<br/>Mice<br/>Pentylenetetrazole--antagonists & inhibitors<br/>Postural Balance--drug effects<br/>Protein Binding<br/>Pyridazines--pharmacology<br/>Radioligand Assay<br/>Rats<br/>Rats, Sprague-Dawley<br/>Receptors, GABA-A<br/>Recombinant Proteins--metabolism<br/>Reflex, Startle--drug effects<br/>Saimiri<br/>Substance Withdrawal Syndrome--psychology<br/>Triazoles--pharmacology