Ota, H <br/><br/>
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.  [electronic resource] 

 -  Oncogene  Jan 2006 
 - 176-85 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural 
<br/><br/><label>ISSN: </label>0950-9232 
<br/><br/><label>Standard No.: </label>10.1038/sj.onc.1209049  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Benzamides--pharmacology<br/>Breast Neoplasms--drug therapy<br/>Cellular Senescence--drug effects<br/>Enzyme Activation--drug effects<br/>Epidermal Growth Factor--pharmacology<br/>ErbB Receptors--metabolism<br/>Genes, ras--physiology<br/>Histone Deacetylase Inhibitors<br/>Humans<br/>Insulin-Like Growth Factor I--pharmacology<br/>Lung Neoplasms--drug therapy<br/>Mitogen-Activated Protein Kinase 1--metabolism<br/>Mitogen-Activated Protein Kinase 3--metabolism<br/>Naphthols--pharmacology<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Phosphorylation--drug effects<br/>Plasminogen Activator Inhibitor 1--metabolism<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>Receptor, IGF Type 1--metabolism<br/>Signal Transduction--drug effects<br/>Sirtuin 1<br/>Sirtuins--antagonists & inhibitors<br/>Tumor Cells, Cultured<br/>Tyrosine--metabolism<br/>beta-Galactosidase--metabolism<br/>p38 Mitogen-Activated Protein Kinases--metabolism