Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2. [electronic resource]
- The Journal of biological chemistry Oct 2005
- 36099-109 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.M505291200 doi
Animals Blotting, Northern Blotting, Western Cell Proliferation Collagen--metabolism DNA--chemistry Dose-Response Relationship, Drug Enzyme Activation Fibroblasts--metabolism Fibrosis--metabolism Genotype Green Fluorescent Proteins--metabolism Homozygote Inflammation Insulin-Like Growth Factor I--metabolism Intestinal Mucosa--metabolism Matrix Metalloproteinase 2--metabolism Mice Mice, Transgenic Mitogen-Activated Protein Kinase 1--metabolism Mitogen-Activated Protein Kinase 3--metabolism NF-kappa B--metabolism Protein Isoforms RNA--metabolism RNA, Messenger--metabolism Receptors, Tumor Necrosis Factor--chemistry Receptors, Tumor Necrosis Factor, Type II--metabolism STAT3 Transcription Factor--metabolism Signal Transduction Time Factors Tissue Inhibitor of Metalloproteinase-1--metabolism Transcription Factor AP-1--metabolism Transcription, Genetic Transcriptional Activation Tumor Necrosis Factor-alpha--metabolism Up-Regulation