TY - GEN AU - Menzella,Hugo G AU - Reid,Ralph AU - Carney,John R AU - Chandran,Sunil S AU - Reisinger,Sarah J AU - Patel,Kedar G AU - Hopwood,David A AU - Santi,Daniel V TI - Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes SN - 1087-0156 PY - 2005///1221 KW - Amino Acid Sequence KW - Biotechnology KW - methods KW - Combinatorial Chemistry Techniques KW - Escherichia coli KW - metabolism KW - Genetic Engineering KW - Lactones KW - chemistry KW - Macrolides KW - Models, Chemical KW - Molecular Sequence Data KW - Plasmids KW - Polyketide Synthases KW - biosynthesis KW - Protein Engineering KW - Protein Structure, Tertiary KW - Sequence Homology, Amino Acid N1 - Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S UR - https://doi.org/10.1038/nbt1128 ER -