Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action. [electronic resource]
- Biochemistry Aug 2005
- 11067-73 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0006-2960
10.1021/bi0508845 doi
Amino Acid Substitution--genetics Animals Binding Sites--genetics Blood Glucose--drug effects Chelating Agents--administration & dosage Diabetes Mellitus, Experimental--drug therapy Dose-Response Relationship, Drug Drug Synergism Enzyme Activation--drug effects Galactosamine--administration & dosage Hydrogen Bonding--drug effects Inositol--administration & dosage Inositol Phosphates--administration & dosage Insulin--administration & dosage Male Manganese--chemistry Models, Molecular Nitrophenols--chemistry Organophosphorus Compounds--chemistry Phosphoprotein Phosphatases--chemistry Point Mutation Protein Binding--genetics Protein Phosphatase 2C Protein Structure, Tertiary--genetics Rats Rats, Sprague-Dawley