TY  - GEN
AU  - Guo,Zhiqiang
AU  - Tellew,John E
AU  - Gross,Raymond S
AU  - Dyck,Brian
AU  - Grey,Jonathan
AU  - Haddach,Mustapha
AU  - Kiankarimi,Mehrak
AU  - Lanier,Marion
AU  - Li,Bin-Feng
AU  - Luo,Zhiyong
AU  - McCarthy,James R
AU  - Moorjani,Manisha
AU  - Saunders,John
AU  - Sullivan,Robert
AU  - Zhang,Xiaohu
AU  - Zamani-Kord,Said
AU  - Grigoriadis,Dimitri E
AU  - Crowe,Paul D
AU  - Chen,Ta Kung
AU  - Williams,John P
TI  - Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists
SN  - 0022-2623
PY  - 2005///0927
KW  - Administration, Oral
KW  - Adrenocorticotropic Hormone
KW  - blood
KW  - Animals
KW  - Blood-Brain Barrier
KW  - metabolism
KW  - CHO Cells
KW  - Corticotropin-Releasing Hormone
KW  - pharmacology
KW  - Cricetinae
KW  - Cricetulus
KW  - Cyclic AMP
KW  - antagonists & inhibitors
KW  - Drug Design
KW  - Heterocyclic Compounds, 3-Ring
KW  - chemical synthesis
KW  - Humans
KW  - Imidazoles
KW  - Injections, Intravenous
KW  - Male
KW  - Pyridines
KW  - Radioligand Assay
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Receptors, Corticotropin-Releasing Hormone
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - CRF Receptor, Type 1
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm050384+
ER  -