TY - GEN AU - Luckman,Steven P AU - Hughes,David E AU - Coxon,Fraser P AU - Russell,Graham G AU - Rogers,Michael J TI - JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998) SN - 0884-0431 PY - 2005///0920 KW - Animals KW - Bone Resorption KW - history KW - Cells, Cultured KW - Diphosphonates KW - GTP-Binding Proteins KW - History, 20th Century KW - Lovastatin KW - analogs & derivatives KW - Mevalonic Acid KW - Mice KW - Osteoclasts KW - drug effects KW - Protein Prenylation KW - ras Proteins N1 - Publication Type: Biography; Classical Article; Historical Article; Journal Article UR - https://doi.org/10.1359/jbmr.2005.20.7.1265 ER -