TY - GEN AU - Murali,Ramachandran AU - Cheng,Xin AU - Berezov,Alan AU - Du,Xiulian AU - Schön,Arnie AU - Freire,Ernesto AU - Xu,Xiaowei AU - Chen,Youhai H AU - Greene,Mark I TI - Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107 SN - 0027-8424 PY - 2005///0920 KW - Allosteric Site KW - genetics KW - Amino Acid Substitution KW - Animals KW - Arthritis, Experimental KW - Base Sequence KW - Cell Line KW - DNA KW - Humans KW - In Vitro Techniques KW - Male KW - Mice KW - Mice, Inbred DBA KW - Models, Molecular KW - Mutagenesis, Site-Directed KW - NF-kappa B KW - metabolism KW - Protein Conformation KW - Receptors, Tumor Necrosis Factor, Type I KW - antagonists & inhibitors KW - Signal Transduction KW - Tryptophan KW - chemistry KW - Tumor Necrosis Factor-alpha KW - p38 Mitogen-Activated Protein Kinases N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1073/pnas.0504301102 ER -