TY  - GEN
AU  - Künzler,Dominik E
AU  - Sasso,Severin
AU  - Gamper,Marianne
AU  - Hilvert,Donald
AU  - Kast,Peter
TI  - Mechanistic insights into the isochorismate pyruvate lyase activity of the catalytically promiscuous PchB from combinatorial mutagenesis and selection
SN  - 0021-9258
PY  - 2005///1128
KW  - Amino Acid Sequence
KW  - Bacterial Proteins
KW  - chemistry
KW  - Binding Sites
KW  - Catalysis
KW  - Cell Proliferation
KW  - Chorismate Mutase
KW  - Circular Dichroism
KW  - DNA-Directed RNA Polymerases
KW  - Dose-Response Relationship, Drug
KW  - Escherichia coli
KW  - metabolism
KW  - Evolution, Molecular
KW  - Gene Expression Regulation
KW  - Gene Expression Regulation, Enzymologic
KW  - Gene Library
KW  - Genetic Techniques
KW  - Glutamic Acid
KW  - Glutamine
KW  - Hydrogen-Ion Concentration
KW  - Kinetics
KW  - Models, Biological
KW  - Models, Chemical
KW  - Molecular Sequence Data
KW  - Mutagenesis
KW  - Mutagenesis, Site-Directed
KW  - Mutation
KW  - Oxo-Acid-Lyases
KW  - Plasmids
KW  - Protein Conformation
KW  - Protein Structure, Tertiary
KW  - Pseudomonas aeruginosa
KW  - enzymology
KW  - Sequence Homology, Amino Acid
KW  - Spectrophotometry
KW  - Viral Proteins
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1074/jbc.M506883200
ER  -