TY  - GEN
AU  - Shimamura,Takeshi
AU  - Lowell,April M
AU  - Engelman,Jeffrey A
AU  - Shapiro,Geoffrey I
TI  - Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
SN  - 0008-5472
PY  - 2005///0914
KW  - Animals
KW  - Antibiotics, Antineoplastic
KW  - pharmacology
KW  - Apoptosis
KW  - drug effects
KW  - Benzoquinones
KW  - Carcinoma, Non-Small-Cell Lung
KW  - drug therapy
KW  - Cell Line, Tumor
KW  - Cyclin D1
KW  - metabolism
KW  - Cysteine Proteinase Inhibitors
KW  - ErbB Receptors
KW  - genetics
KW  - Gene Deletion
KW  - HSP90 Heat-Shock Proteins
KW  - antagonists & inhibitors
KW  - Humans
KW  - Lactams, Macrocyclic
KW  - Lung Neoplasms
KW  - Mice
KW  - Mitogen-Activated Protein Kinase 1
KW  - Mitogen-Activated Protein Kinase 3
KW  - NIH 3T3 Cells
KW  - Phosphorylation
KW  - Protein Serine-Threonine Kinases
KW  - Protein Structure, Tertiary
KW  - Proto-Oncogene Proteins
KW  - Proto-Oncogene Proteins c-akt
KW  - Quinones
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1158/0008-5472.CAN-05-0933
ER  -