TY  - GEN
AU  - Coudray,Anne-Marie
AU  - Louvet,Christophe
AU  - Kornprobst,Michel
AU  - Raymond,Eric
AU  - André,Thierry
AU  - Tournigand,Christophe
AU  - Faivre,Sandrine
AU  - De Gramont,Aimery
AU  - Larsen,Annette K
AU  - Gespach,Christian
TI  - Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independent mechanisms
SN  - 1019-6439
PY  - 2005///1223
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Apoptosis
KW  - drug effects
KW  - Breast Neoplasms
KW  - metabolism
KW  - Camptothecin
KW  - analogs & derivatives
KW  - Caspase 3
KW  - Caspase Inhibitors
KW  - Caspases
KW  - Cell Cycle
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - Colorectal Neoplasms
KW  - Cysteine Proteinase Inhibitors
KW  - DNA Topoisomerases, Type I
KW  - Dose-Response Relationship, Drug
KW  - Drug Synergism
KW  - Enzyme Inhibitors
KW  - Fluorouracil
KW  - Folic Acid Antagonists
KW  - Glutamates
KW  - Guanine
KW  - HT29 Cells
KW  - Humans
KW  - Intracellular Signaling Peptides and Proteins
KW  - Irinotecan
KW  - Oligopeptides
KW  - Organoplatinum Compounds
KW  - Oxaliplatin
KW  - Pemetrexed
KW  - Protein Serine-Threonine Kinases
KW  - Quinazolines
KW  - Thymidylate Synthase
KW  - antagonists & inhibitors
KW  - Time Factors
KW  - Topoisomerase I Inhibitors
KW  - rho-Associated Kinases
N1  - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
ER  -