Basso, Andrea D <br/><br/>
The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.  [electronic resource] 

 -  The Journal of biological chemistry  Sep 2005 
 - 31101-8 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0021-9258 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M503763200  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Alkyl and Aryl Transferases--antagonists & inhibitors<br/>Animals<br/>Antineoplastic Agents--therapeutic use<br/>Bridged-Ring Compounds--therapeutic use<br/>Caspases--metabolism<br/>Cell Line, Tumor<br/>Farnesyltranstransferase<br/>Humans<br/>Monomeric GTP-Binding Proteins--genetics<br/>Neoplasms--drug therapy<br/>Neuropeptides--genetics<br/>Phosphorylation<br/>Piperidines--metabolism<br/>Protein Kinases--genetics<br/>Protein Prenylation<br/>Pyridines--metabolism<br/>RNA, Messenger--metabolism<br/>Ras Homolog Enriched in Brain Protein<br/>Recombinant Fusion Proteins--genetics<br/>Signal Transduction--physiology<br/>TOR Serine-Threonine Kinases<br/>Tamoxifen--therapeutic use<br/>Taxoids--therapeutic use